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| 折扣與優(yōu)惠：團購最低可5折優(yōu)惠 - 了解詳情 | 論文格式：Word格式(*.doc) |  |
摘要：玫瑰樹生物堿是夾竹桃科蘿芙木亞科玫瑰樹屬植物玫瑰樹中特有的一類單萜吲哚生物堿及二聚體[1]。單萜吲哚生物堿是一類結構變化多樣的天然產(chǎn)物，它是由色氨酸(tryptamine)和裂環(huán)馬錢子甙(secologanin)縮合產(chǎn)生的異胡豆甙(strictosidine)經(jīng)過一系列骨架變化(C-C、C-N、C-O鍵的形成和/或斷裂)衍生而來的[2][5]。玫瑰樹的化學成分研究報道主要是在上個世紀60年代，最近法國科學家從同屬的莫氏玫瑰樹(O. moorei)中發(fā)現(xiàn)玫瑰樹堿(ellipticine) 能作用于蛋白激酶CK2，這是吲哚生物堿作用機制研究取得的重要進展[3]。出于對該屬生物堿成分抗腫瘤和抗炎活性成分的興趣，本論文對玫瑰樹生物堿的化學成分進行了研究，利用各種柱層析和高效液相色譜等分離手段，并結合現(xiàn)代波譜分析技術等方法從中分離鑒定了2個生物堿成分的化學結構。 關鍵詞：夾竹桃科；蘿芙木亞科；玫瑰樹；單萜吲哚生物堿；波譜分析技術
ABSTRACT：Alkaloids of the ochrosia borbonica are a class of special monoterpenoid indole alkaloids and dimmers，which included in the plant of rosae that attributable to the subfamily of the rauwolfia that is one of the branches of apocynaceae.[1] Monoterpenoid indole alkaloids is a class of natural products that has variety of structural changes, which is condensate generated from the tryptamine and split ring secologanin and glycosides of strictosidine as the condensed product after by a series of skeleton changes(such as bond formation or bond fracture in C-C,C-N,C-O etc) to derivative. [2][5]The research reports on the chemical composition of rosae was traced back to the 60's of last century, recently a study by French scientists shows that the alkaloids of the ochrosia borbonica discovered from the Morse rose tree (o. moored) can act on the protein kinas CK2, which is a significant progress on the study for mechanism of indole alkaloids [3]. For the research interests on the active ingredients that derived from the alkaloids isolated from this class of plant that can take role in anti-tumor and anti-inflammatory , this paper has studied the chemical composition of rosae alkaloids, within the study, we have used the separation methods such as a variety of column chromatography and High Performance Liquid Chromatography and combined with modern spectral analysis techniques, as a return that tow chemical structure of alkaloids have been isolated and identificated. Key words: Apocynaceae; Subfamily of the Rauwolfia; Rosae; Monoterpenoid indole alkaloids; Spectral analysis |
