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| 折扣與優(yōu)惠：團(tuán)購最低可5折優(yōu)惠 - 了解詳情 | 論文格式：Word格式(*.doc) |  |
摘要:馬錢子Strychnos nux-vomica L.屬于馬錢科（loganiacena）常綠喬木，主要分布于熱帶和亞熱帶地區(qū)。我國海南、云南有分布。馬錢子在我國作為藥用有悠久的歷史，具有散血熱 、消腫、止痛等功效。近年來，馬錢子廣泛應(yīng)用于各種腫瘤的臨床治療，取得了較好的療效，成為了抗腫瘤研究的一個(gè)熱點(diǎn)。對馬錢子藥用有效成分進(jìn)行提取分離和結(jié)構(gòu)鑒定，有利于其藥用資源的深層次開發(fā)，提高其藥用價(jià)值。目前，國內(nèi)外對本屬植物化學(xué)成分的研究報(bào)道并不多，為了更深入地了解其化學(xué)成分并從中尋找活性化合物，本論文對馬錢子的化學(xué)成分進(jìn)行了較為系統(tǒng)的研究。通過硅膠柱色譜、SephadexLH-20柱色譜、開放ODS柱色譜、制備HPLC等多種色譜手段，從馬錢子的90%乙醇提取物中共分離得到5個(gè)化合物，并通過理化常數(shù)測定、波譜數(shù)據(jù)分析等手段，鑒定了它們的結(jié)構(gòu)。分別為：番木鱉次堿、番木鱉氮氧化合物、奴弗新、strychnine methiodide和brucine。 關(guān)鍵詞：馬錢子；化學(xué)成分；提取與分離
Abstract:Strychnos nux-vomica L. that belong to loganiacena is a green smallish tree, growing mainly in the tropical zone and subtropical zone. It is distributed in Hainan and Yunnan province in China. As a pharmaceutical product, Strychnos nux-vomica L. has a long history in our country. It showed the physiological functions such as scattering heat in blood, detumescence, alleviating pain and so on. Recent years, it was widely used for clinical therapy of various kinds of cancer and got better therapeutic effect. It has become a hot spot of anticancer study. For the purpose of finding much more bioactive agents from this plant and to supply its exploitation, the further chemical study of this plant was carried out. At present, little chemical work about its chemical constituents has been reported. In order to investigate its chemical compositions and look for active compositions, the seeds of Strychnos nux-vomica L. was subjected to detailed phytochemistry studies. The chemical constituents of the 90% ETOH extract from the seeds of Strychnos nux–vomica L. were studied systematically. Five compounds were isolated by repeated silica gel, sephadex LH-20 columns chromatography and preparation HPLC. And they were identified as vomicine, strychnine-N-oxide, novacine, strychnine methiodide, brucine. Key words: Strychnos nux-vomica L.; chemical constituents; extraction and separation |
